招聘簡介：
該職位可立即獲得高動力博士學(xué)位，重點是使用造血干細(xì)胞（hscs）和基因療法治療多系統(tǒng)退行性疾病的遺傳途徑，尤其是神經(jīng)肌肉疾病。本項目采用的基因治療技術(shù)包括慢病毒載體和CRISPR/CAS9介導(dǎo)的基因編輯。候選人還將使用人類和小鼠的HSC體外檢測和小鼠遺傳疾病模型。該項目還包括對HSC衍生細(xì)胞拯救退化神經(jīng)肌肉組織的機制的研究。成功的候選人將成為一個具有尖端儀器和設(shè)施的刺激性和協(xié)作性科學(xué)環(huán)境的一部分。
英文原文：
Available immediately for highly motivated Ph.Ds, the position focuses on the use of hematopoietic stem cells (HSCs) and gene therapy for the treatment of inherited approaches for multi-systemic degenerative disorders, and in particular neuromuscular diseases. Gene therapy technologies employed in the project include lentivirus vectors and CRISPR/Cas9-mediated gene editing. The candidate will also use human and mouse HSCs in in vitro assays and murine models of genetic disorders. The project also includes the investigation of the mechanism involved in the rescue of degenerative neuromuscular tissues by HSC-derived cells. Successful Candidates will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities.
Qualifications Required and Preferred Academic Background
The candidate should be highly self-motivated, with strong communication and interpersonal skills and the ability to work independently, has a PhD, with a strong background in stem cell biology, gene therapy and CRISPR/Cas9-mediated gene editing and neuroscience. Experience with mice is required.
If you are interested, please submit your C.V. to Stephanie Cherqui scherqui@ucsd.edu.
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