招聘簡介：

　　骨髓瘤分子機(jī)制博士后研究員

　　·希望之城

　　·地點(diǎn)：加利福尼亞州杜阿爾特

　　·工作編號(hào)：7057370

　　·發(fā)布日期：2019年5月20日

　　職位描述

　　希望之城貝克曼研究所正在尋找一位有才華的博士后研究員，成為血液惡性腫瘤和干細(xì)胞移植研究所的Pichiorri實(shí)驗(yàn)室的一個(gè)組成部分。

　　我們的長期目標(biāo)是闡明骨髓瘤發(fā)展的分子機(jī)制和治療后獲得性抵抗機(jī)制的顛覆。因此，成功的候選人將參與與骨髓瘤發(fā)展相關(guān)的微環(huán)境、遺傳和表觀遺傳變化的研究，包括但不限于糖尿病易患癌癥和使用不同骨髓瘤小鼠模型、原始樣本和體內(nèi)相關(guān)研究的小的非編碼RNA。在該部門的大力支持下，其主要目標(biāo)之一是促進(jìn)發(fā)現(xiàn)治療骨髓瘤的新治療靶點(diǎn)，并制定具體的第一階段試驗(yàn)，以彌合基礎(chǔ)科學(xué)與臨床實(shí)踐之間的差距。

　　英文原文：

　　Postdoctoral Fellow - Molecular Mechanisms of Myeloma

　　·         City of Hope

　　·         Location: Duarte, CA

　　·         Job Number: 7057370

　　·         Posting Date: May 20, 2019

　　Job Description

　　The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow to become an integral part of Pichiorri Lab, within the Division of Hematologic Malignancies and Stem Cell Transplantation Institute.

　　Our long-term goal is to elucidate the molecular mechanism(s) underlying the development of myeloma and the insurgence of mechanisms of acquired resistance upon treatments. As such, the successful candidate will participate in the investigation of microenvironmental, genetic and epigenetic changes associated with myeloma development, including but not limited to diabetes predisposition to cancer and small non coding RNAs using different myeloma mouse models, primary samples and in vivo correlative studies. With strong support from the department, one of the main goals is to foster the discovery of novel therapeutic targets for the treatment of myeloma and to develop specific Phase 1 trial for bridging the gap between basic science and clinical practice.

　　Basic education, experience and skills required for consideration:

　　A Ph.D. degree in biology, life or biomedical sciences, or a related discipline is required;

　　Experience in recombinant protein production for cellular drug high throughput screening, protein purification and protein-protein interaction;

　　Experience in DNA damage;

　　In vitro cell culture: human and mouse cells, leukemia, myeloma, cell transfections and drugs treatments;

　　Experience in mouse bone marrow transplant (BMT) and engraftment studies;

　　Experience with any of the animal cancer models: leukemia/myeloma or solid tumors (breast, prostate, liver);

　　Experience in multicolor flow cytometry, RNA, DNA isolation and preparation, QRT-PCR, Elisa assay, Western blot, IP techniques, Cloning and Luciferase assay.

　　Additional Information:

　　For more information about Dr. Pichiorri’s research, please visit: https://www.cityofhope.org/people/pichiorri-flavia.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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