招聘簡介：

　　博士后助理（眼科-藥物發(fā)現(xiàn)/開發(fā)）

　　·邁阿密大學

　　·地點：佛羅里達州邁阿密

　　·工作編號：7057369（參考號：R100030943）

　　·發(fā)布日期：2019年5月20日

　　·申請截止日期：開放至填寫

　　職位描述

　　邁阿密大學米勒醫(yī)學院巴斯科-帕爾默眼科研究所的眼科正在尋找兩名積極的博士后助理，他們在分子/細胞生物學和動物研究方面具有豐富的研究經(jīng)驗，有助于發(fā)現(xiàn)和開發(fā)生物藥物。這些職位是美國國立衛(wèi)生研究院資助的在巴斯科姆帕爾默眼科研究所開發(fā)新型藥物療法的項目的一部分�！睹绹�新聞與世界報道》（U.S.News and World Report）連續(xù)15年（2004-2018年）將巴斯科姆帕爾默眼科研究所列為1眼科醫(yī)院。

　　研究將集中于開發(fā)下一代針對各種血管疾病的靶向抗血管生成療法。實驗室最近開發(fā)了唯一一種具有廣泛適用性的配體組學技術，以發(fā)現(xiàn)不同疾病（包括但不限于血管生成性疾�。┑男炉煼ǖ母哔|量藥物靶點（PMID:29326083）。利用這項強大的技術，我們發(fā)現(xiàn)了非常有希望的藥物靶點，并正在開發(fā)針對各種眼部血管疾病的靶點抗血管生成療法（PMID:28330905）。該項目將在不同階段對候選藥物進行調查。這些包括動物模型中治療血管生成性疾病的人源化抗體的特征描述，體外和體內(nèi)新藥物靶點的分析，以及發(fā)現(xiàn)其他未知藥物靶點的配體組學篩選。研究活動包括配體組學分析、分子和細胞研究、蛋白質分析、抗體表征、受體識別和表征、治療血管滲漏和動物模型病理性新生血管的療法、臨床前毒理學和藥代動力學研究。

　　英文原文：

　　Postdoctoral Associate (Ophthalmology - Drug Discovery/Development)

　　·         University of Miami

　　·         Location: Miami, FL

　　·         Job Number: 7057369 (Ref #: R100030943)

　　·         Posting Date: May 20, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Department of Ophthalmology at the Bascom-Palmer Eye Institute, University of Miami Miller School of Medicine is searching for two highly-motivated Postdoctoral Associates with strong research experience in molecular/cellular biology and animal research for biological drug discovery and development. These positions are part of NIH-funded projects to develop novel drug therapies at Bascom Palmer Eye Institute. Bascom Palmer Eye Institute has been ranked as the #1 eye hospital in the past 15 consecutive years (2004 -2018) by U.S. News and World Report.

　　Research will focus on developing next-generation targeted anti-angiogenic therapies for various vascular diseases. The laboratory recently developed the only technology of ligandomics with broad applicability to discover high-quality drug targets for novel therapies of different diseases, including but not limited to angiogenic diseases (PMID: 29326083). Using this powerful technology, we discovered highly promising drug targets and are developing targeted anti-angiogenic therapies for various ocular vascular diseases (PMID: 28330905). This project will investigate drug candidates in various stages. These include characterization of humanized antibodies to treat angiogenic diseases in animal models, analysis of novel drug targets in vitro and in vivo, and ligandomics screening to discover additional unknown drug targets. The research activities include ligandomics analysis, molecular and cellular studies, protein analyses, antibody characterizations, receptor identification and characterization, therapies to treat vascular leakage and pathological neovascularization in animal models, preclinical toxicology and pharmacokinetics studies.

　　Minimum Qualifications

　　Candidates must have a Ph.D. and/or MD, have productive scientific contributions through publication of high impact peer-reviewed papers, and show strong commitment to science. Applicants with advanced skills in molecular biology, cell biology, protein biochemistry, immunohistochemistry and animal research are highly desired. Experience in bioinformatics analysis is a plus. Excellent verbal and written communication skills are required. This position represents an excellent opportunity for career development in disease mechanism research and drug target discovery.

　　If interested, please complete an online application and send a CV, 1-2 page summary/Cover letter describing past accomplishments and 3 references, including contact information to Dr. Wei Li at w.li@med.miami.edu. Salary is based on NIH recommendation. Positions are available immediately.

　　UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

　　Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University of Miami School of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

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