招聘簡介：

　　·莫菲特癌癥中心和研究所

　　·地點(diǎn)：佛羅里達(dá)州坦帕市

　　職位描述

　　H. Lee Moffitt癌癥中心和研究所為轉(zhuǎn)化肺癌研究的博士后學(xué)者開設(shè)了一個研討會。 Haura實(shí)驗(yàn)室追求跨學(xué)科方法，涵蓋蛋白質(zhì)組學(xué)，化學(xué)生物學(xué)，轉(zhuǎn)化醫(yī)學(xué)，分子生物學(xué)，生物化學(xué)和生物信息學(xué)，以表征癌癥信號網(wǎng)絡(luò)的系統(tǒng)級視圖。特別強(qiáng)調(diào)整合功能蛋白質(zhì)組學(xué)技術(shù)，例如，化學(xué)和磷酸化蛋白質(zhì)組學(xué)，剖析藥物作用和癌癥生物學(xué)的潛在機(jī)制。見http://labpages.moffitt.org/haurae/Home.html

　　我們正在尋找一位具有跨學(xué)科技能的科學(xué)家，他有興趣使用鄰近連接測定（PLA）技術(shù)從事與蛋白質(zhì)復(fù)合物注釋相關(guān)的項(xiàng)目（Smith，Science Signaling，2015; Smith，Clinical Cancer Research，2017）。該項(xiàng)目將包括使用人肺癌組織的現(xiàn)有EGFR和MET鄰近測定的臨床驗(yàn)證研究。該候選人將確定我們機(jī)構(gòu)的肺癌標(biāo)本中EGFR PLA的發(fā)生率，并使用由試驗(yàn)相關(guān)的肺癌標(biāo)本組成的多個外部隊(duì)列研究EGFR PLA與EGFR定向治療反應(yīng)的關(guān)聯(lián)。

　　英文原文：

　　·         Moffitt Cancer Center and Research Institute

　　·         Location: Tampa, FL

　　Job Description

　　The H. Lee Moffitt Cancer Center and Research Institute has an opening for a postdoctoral scholar in translational lung cancer research. The Haura lab pursues an interdisciplinary approach spanning proteomics, chemical biology, translational medicine, molecular biology, biochemistry, and bioinformatics to characterize systems level views of cancer signaling networks. Particular emphasis is given to integrating functional proteomics technologies, e.g. chemical and phosphoproteomics, to dissect the underlying mechanism of drug action and cancer biology. See http://labpages.moffitt.org/haurae/Home.html

　　We are looking for a scientist with a cross-disciplinary skill set who is interested in working on projects related to protein complex annotation using proximity ligation assay (PLA) technology (Smith, Science Signaling, 2015; Smith, Clinical Cancer Research, 2017). The project will consist of clinical validation studies of existing EGFR and MET proximity assays using human lung cancer tissues. The candidate will define the incidence of EGFR PLA in lung cancer specimens from our institution and investigate the association of EGFR PLA with response to EGFR-directed therapies using multiple external cohorts, consisting of trial-associated lung cancer specimens.

　　The successful candidate must hold a PhD in cancer biology (or related discipline) and have extensive experience with immunohistochemistry, analytical microscopy, human subjects research and modern molecular biology techniques. A firm understanding of predictive biomarker strategies, intracellular signaling and basic statistical concepts will be highly beneficial. Candidates with experience in cancer pathology and/or tissue based imaging will be given priority. The position requires the ability to operate in an independent manner with limited supervision and to lead collaborative efforts across multiple disciplines within Moffitt and external industry collaborators. Strong written and verbal communication skills will be required. Opportunities for travel to relevant conferences, grant writing and mentoring are available.

　　Interested candidates should send CV, cover letter describing research interests and 2-3 references to Eric.Haura@moffitt.org.

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