招聘簡介：
立即可用于高度積極的博士，該職位的重點是使用造血干細(xì)胞（HSCs）和基因療法治療多系統(tǒng)退行性疾病，特別是神經(jīng)肌肉疾病的遺傳方法。該項目中使用的基因治療技術(shù)包括慢病毒載體和CRISPR / Cas9介導(dǎo)的基因編輯。候選人還將在體外測定和遺傳疾病的鼠模型中使用人和小鼠HSC。該項目還包括調(diào)查HSC衍生細(xì)胞拯救退行性神經(jīng)肌肉組織所涉及的機制。成功的候選人將成為具有尖端儀器和設(shè)施的激動人心的合作科學(xué)環(huán)境的一部分。
英文原文：
Available immediately for highly motivated Ph.Ds, the position focuses on the use of hematopoietic stem cells (HSCs) and gene therapy for the treatment of inherited approaches for multi-systemic degenerative disorders, and in particular neuromuscular diseases. Gene therapy technologies employed in the project include lentivirus vectors and CRISPR/Cas9-mediated gene editing. The candidate will also use human and mouse HSCs in in vitro assays and murine models of genetic disorders. The project also includes the investigation of the mechanism involved in the rescue of degenerative neuromuscular tissues by HSC-derived cells. Successful Candidates will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities.
Qualifications Required and Preferred Academic Background
The candidate should be highly self-motivated, with strong communication and interpersonal skills and the ability to work independently, has a PhD, with a strong background in stem cell biology, gene therapy and CRISPR/Cas9-mediated gene editing and neuroscience. Experience with mice is required.
If you are interested, please submit your C.V. to Stephanie Cherqui scherqui@ucsd.edu.
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