招聘簡介：

　　博士后研究員 - 血液學(xué) - 腫瘤學(xué)和免疫學(xué)

　　·希望之城

　　·地點：加利福尼亞州杜阿爾特

　　·工作號碼：7057373

　　·發(fā)布日期：2019年5月20日

　　·申請截止日期：開放至填寫

　　職位描述

　　希望之城貝克曼研究所正在尋找一位才華橫溢，積極進(jìn)取的博士后研究員，該系在生物系統(tǒng)生物學(xué)系新建的Srividya Swaminathan博士實驗室。該實驗室專注于了解B-和T-淋巴惡性腫瘤周圍的免疫微環(huán)境。通過比較正常和惡性淋巴細(xì)胞生成期間的全球免疫景觀，將鑒定出特異性靶向惡性淋巴細(xì)胞的免疫療法。研究范圍包括血液學(xué)，腫瘤學(xué)和免疫腫瘤學(xué)。用淋巴惡性腫瘤的轉(zhuǎn)基因小鼠模型，原代人淋巴癌細(xì)胞，人源化小鼠，研究惡性淋巴細(xì)胞和宿主免疫之間相互作用的移植模型，基因編輯，經(jīng)典分子和細(xì)胞生物學(xué)以及致癌信號轉(zhuǎn)導(dǎo)進(jìn)行實驗。

　　英文原文：

　　Postdoctoral Fellow - Hematology-Oncology and Immunology

　　·         City of Hope

　　·         Location: Duarte, CA

　　·         Job Number: 7057373

　　·         Posting Date: May 20, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Beckman Research Institute of City of Hope is looking for a talented and motivated Postdoctoral Fellow in the newly established laboratory of Dr. Srividya Swaminathan in the Department of Systems Biology. The lab is focused on understanding the immune microenvironment surrounding B- and T- lymphoid malignancies. By comparing the global immune landscape during normal and malignant lymphopoiesis, immunotherapies will be identified that specifically target malignant lymphocytes. Research spans Hematology, Oncology, and Immuno-Oncology. Experiments are performed with transgenic mouse models of lymphoid malignancies, primary human lymphoid cancer cells, humanized mice, transplantation models to study interactions between malignant lymphocytes and host immunity, gene editing, classical molecular and cell biology, and oncogenic signal transduction.

　　Methods that will be extensively utilized but not limited to are:

　　Immune profiling (flow cytometry, mass cytometry (CyTOF), CIBERSORT)

　　In vivo assays (mouse genetics, intravenous and intrafemoral transplantation assays, humanized mouse models of lymphoma, pre-clinical testing of cell-based and other immunotherapies in xenotransplantation models, bioluminescence imaging)

　　Molecular biology and biochemistry (retroviral/lentiviral transduction, molecular cloning, RNA/DNA sequencing, qPCR, immunoblotting, immunofluorescence, luminex)

　　Basic education, experience and skills required for consideration:

　　PhD in Immunology, Cell, Molecular biology, life or biomedical sciences, or a related discipline is required;

　　Enthusiasm for science, and willingness to think beyond established concepts;

　　Experience with flow cytometry, and prior experience with handling mice and performing in vivo procedures (strongly desired);

　　Enthusiasm to learn new experimental and computational data analysis tools;

　　Highly independent with excellent organizational skills;

　　Collaborative team player.

　　Additional Information:

　　Application should include Curriculum Vitae and coordinates of three scientific mentors;

　　Application should include a cover letter highlighting research interests, a brief statement explaining how past research ties in with the goals of this laboratory, and future career plans;

　　For more information about Dr. Swaminathan’s research please click here: https://www.cityofhope.org/research/systems-biology/systems-biology-research-labs/srividya-swaminathan-lab;

　　Recent work: While working as a Postdoctoral Fellow and then as an Instructor at Stanford University, Dr. Swaminathan investigated how oncogenes modulate anti-tumor immune surveillance (Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018: https://www.biorxiv.org/content/10.1101/503086v1; JITC,2018: https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0431-x). Using CyTOF in a primary mouse model of MYC-driven T cell neoplasia, she mechanistically demonstrated the direct and reversible suppression of natural killer (NK) cells by the MYC oncogene. Her studies provide a strong rationale for developing NK cells as a therapy against MYC-driven, and other oncogene-driven lymphoid malignancies that rely on MYC (Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018: https://www.biorxiv.org/content/10.1101/503086v1. Dr. Swaminathan’s laboratory will utilize her extensive research experience in normal and malignant lymphocyte biology (Nature Immunology, 2015: https://www.nature.com/articles/ni.3160; Nature Medicine, 2013: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954721/), in identifying the vulnerabilities specific to malignant lymphocytes. Her laboratory is funded by the Leukemia and Lymphoma Society (LLS): https://www.lls.org/content/induction-of-immunological-memory-to-target-myc-driven-lymphomas, the American Society of Hematology (ASH): https://www.hematology.org/Awards/Award-Recipients/2119.aspx, and City of Hope.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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