招聘簡介：

　　化學(xué)生物學(xué)和有機(jī)/藥物化學(xué)博士后研究員

　　·圣母大學(xué)

　　·地點(diǎn)：巴黎圣母院，IN

　　·工作號碼：7057647

　　·發(fā)布日期：2019年6月10日

　　·申請截止日期：開放至填寫

　　職位描述

　　圣母大學(xué)化學(xué)與生物化學(xué)系Juan Del Valle教授的實(shí)驗(yàn)室目前正在接受兩個(gè)公開博士后職位的申請。

　　第一個(gè)是化學(xué)生物學(xué)領(lǐng)域，研究項(xiàng)目側(cè)重于蛋白質(zhì) - 蛋白質(zhì)相互作用抑制劑和ER應(yīng)激反應(yīng)途徑的生物學(xué)評估和表征。這些靶標(biāo)的調(diào)節(jié)劑將用于治療癌癥和神經(jīng)退行性疾病。職責(zé)包括重組蛋白表達(dá)/純化，體外生化測定的開發(fā)，以及細(xì)胞測定中優(yōu)化抑制劑的評估。

　　第二個(gè)開放職位是有機(jī)/藥物化學(xué)領(lǐng)域。職責(zé)包括生物活性肽模擬物和小分子的設(shè)計(jì)和多步合成，以及基于結(jié)構(gòu)的優(yōu)化以靶向蛋白質(zhì) - 蛋白質(zhì)相互作用。

　　考生必須擁有博士學(xué)位。在化學(xué)，生物學(xué)或相關(guān)領(lǐng)域，并具有良好的書面和口頭溝通技巧。最近將獲得高度積極的博士學(xué)位。畢業(yè)生在以下一個(gè)或多個(gè)領(lǐng)域具有額外經(jīng)驗(yàn)：藥物設(shè)計(jì)，復(fù)雜分子合成，分子藥理學(xué)和結(jié)構(gòu)生物學(xué)。在我們的實(shí)驗(yàn)室參與其他正在進(jìn)行的跨學(xué)科工作將是感興趣的候選人的選擇。

　　申請人應(yīng)提交一份說明感興趣的職位的求職信，完整的簡歷，簡要的博士研究摘要，以及三個(gè)參考jdelvalle@nd.edu的聯(lián)系信息。申請審查將立即開始，并一直持續(xù)到職位填補(bǔ)。請?jiān)L問delvallelab.weebly.com獲取更多信息。

　　英文原文：

　　Postdoctoral Fellowships in Chemical Biology and Organic/Medicinal Chemistry

　　·         University of Notre Dame

　　·         Location: Notre Dame, IN

　　·         Job Number: 7057647

　　·         Posting Date: Jun 10, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The laboratory of Prof. Juan Del Valle in the Department of Chemistry & Biochemistry at the University of Notre Dame is currently accepting applications for two open Postdoctoral positions.

　　The first is in the area of Chemical Biology, with research projects focused on the biological evaluation and characterization of inhibitors of protein-protein interactions and ER stress response pathways. Modulators of these targets will be applied to the treatment of cancer and neurodegenerative disorders. Duties will include recombinant protein expression/purification, development of in vitro biochemical assays, and evaluation of optimized inhibitors in cellular assays.

　　The second open position is in the area of Organic/Medicinal Chemistry. Duties will include the design and multi-step synthesis of biologically active peptidomimetics and small molecules, and structure-based optimization to target protein-protein interactions.

　　Candidates must have a Ph.D. in Chemistry, Biology, or a related field, and possess excellent written and oral communication skills. Priority will be given to highly motivated, recent Ph.D. graduates with additional experience in one or more of the following areas: drug design, complex molecule synthesis, molecular pharmacology, and structural biology. Involvement in other ongoing interdisciplinary efforts in our laboratory will be an option for interested candidates.

　　Applicants should submit a cover letter indicating the position of interest, complete CV, brief doctoral research summary, and contact information for three references to jdelvalle@nd.edu. Review of applications will begin immediately and continue until the positions are filled. Please visit delvallelab.weebly.com for more information.

　　The University of Notre Dame has exceptional facilities for conducting biomedical research, including state-of-the-art NMR, mass spectrometry, crystallography, microscopy, genomics, and imaging facilities, among others. The successful candidate will have access to an array of resources throughout the College of Science and in the Warren Family Research Center for Drug Discovery and Development, which includes Biological Screening, Chemical Synthesis, and Computer-aided Molecular Design Core Facilities. The Del Valle laboratory and the Warren Center are housed in recently completed McCourtney Hall, a 220,000 square foot building dedicated to research in the molecular sciences and engineering.

　　Postdoctoral Scholars at the University of Notre Dame enjoy a highly competitive compensation and benefits package that includes a retirement plan, medical/dental/vision insurance, paid-time-off, parental leave, and educational reimbursement, among other benefits. The University of Notre Dame seeks to attract, develop, and retain the highest quality faculty, staff and administration. The University is an Equal Opportunity Employee and is committed to building a culturally diverse workplace.

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