招聘簡(jiǎn)介：

　　·貝勒醫(yī)學(xué)院

　　·地點(diǎn)：德克薩斯州休斯頓

　　·工作號(hào)碼：7057704（參考號(hào)：208172SM）

　　·發(fā)布日期：2019年6月13日

　　·申請(qǐng)截止日期：開放至填寫

　　職位描述

　　候選人應(yīng)該獲得生物醫(yī)學(xué)科學(xué)博士學(xué)位，重點(diǎn)是癌癥免疫學(xué)和/或腫瘤微環(huán)境。此外，強(qiáng)大的技術(shù)技能，計(jì)算機(jī)和數(shù)學(xué)能力，以及組織和判斷技能是必不可少的。該項(xiàng)目的重點(diǎn)是用嵌合抗原受體T細(xì)胞進(jìn)行癌癥免疫治療。該項(xiàng)目將涉及細(xì)胞生物學(xué)，分子生物學(xué)和免疫學(xué)領(lǐng)域的實(shí)驗(yàn)。使用的技術(shù)包括但不限于：

　　·從血液樣品中分離人細(xì)胞，細(xì)胞分選，鼠和人細(xì)胞系的培養(yǎng)，用質(zhì)粒和/或病毒載體轉(zhuǎn)導(dǎo)細(xì)胞。

　　·Elispot檢測(cè); FACS分析;細(xì)胞毒性測(cè)定

　　·DNA / RNA提取，PCR，克隆，Western印跡分析

　　·動(dòng)物實(shí)驗(yàn)評(píng)估CAR T細(xì)胞對(duì)異種移植小鼠模型的安全性和抗腫瘤作用此外，還需要獨(dú)立規(guī)劃實(shí)驗(yàn)，撰寫手稿，摘要和授權(quán)申請(qǐng)，以及指導(dǎo)學(xué)生。

　　需要：

　　·生物醫(yī)學(xué)科學(xué)或相關(guān)專業(yè)博士學(xué)位。

　　·在細(xì)胞生物學(xué)，分子生物學(xué)和免疫學(xué)領(lǐng)域的經(jīng)驗(yàn)。

　　英文原文：

　　·         Baylor College of Medicine

　　·         Location: Houston, TX

　　·         Job Number: 7057704 (Ref #: 208172SM)

　　·         Posting Date: Jun 13, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The candidate should have a received a PhD in biomedical sciences, with focus on cancer immunology and/or the tumor microenvironment. In addition, strong technical skills, computer and math abilities, as well as organizational and judgment skills are essential. The project is focused on cancer immunotherapy with Chimeric Antigen Receptor T cells. The project will involve experiments in the areas of cell biology, molecular biology, and immunology. Techniques used include but are not limited to:

　　·         Isolation of human cells from blood samples, cell sorting, culture of murine and human cell lines, transduction of cells with plasmids and/or viral vector.

　　·         Elispot assays; FACS analysis; Cytotoxicity assays

　　·         DNA/RNA extraction, PCR, cloning, Western blot analysis

　　·         Animal experiments to evaluate the safety and antitumor effects of CAR T cells on Xenograft mouse models In addition, independent planning of experiments, writing manuscripts, abstracts, and grant applications, and mentoring students is required.

　　Required:

　　·         PhD in biomedical sciences or related.

　　·         Experience in the areas of cell biology, molecular biology, and immunology.

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