招聘簡介：

　　博士后助理 - 分子與人類遺傳學

　　·貝勒醫(yī)學院

　　·地點：德克薩斯州休斯頓

　　·工作號碼：7057719（參考號：312026KP）

　　·發(fā)布日期：2019年6月13日

　　·申請截止日期：開放至填寫

　　職位描述

　　博士后助理職位可在對動物發(fā)育和人類疾病中糖基化和去糖基化作用感興趣的實驗室中獲得。該實驗室利用細胞培養(yǎng)，果蠅和小鼠遺傳學來鑒定和表征人類疾病基因的遺傳修飾因子，希望能夠揭示疾病病理生理學并建立新的治療靶點。實驗室工作人員與碳水化合物生物化學專家密切合作。該實驗室已經報道了一種稱為Alagille綜合征（ALGS; OMIM 118450）的發(fā)育障礙的小鼠模型，并且在該ALGS模型中鑒定了稱為Poglut1的糖基轉移酶作為膽管表型的顯性遺傳抑制因子（Thakurdas等，Hepatology，2016）。還確定了轉錄因子作為疾病表型的顯性修飾因子，其表達也與人類患者的肝病嚴重程度有很強的相關性（未發(fā)表的數據）。

　　·在這些觀察的基礎上，博士后人員將檢查參與ALGS肝臟異常的遺傳和轉錄網絡，并將研究這些觀察結果對于開發(fā)這種疾病的療法的潛在效用。這些研究可能為疾病背景下的正常膽道發(fā)育和膽道修復提供基本見解。

　　英文原文：

　　Postdoctoral Associate - Molecular and Human Genetics

　　·         Baylor College of Medicine

　　·         Location: Houston, TX

　　·         Job Number: 7057719 (Ref #: 312026KP)

　　·         Posting Date: Jun 13, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　A Postdoctoral Associate position is available in a laboratory interested in the role of glycosylation and deglycosylation in animal development and human disease. The lab uses cell culture, Drosophila and mouse genetics to identify and characterize genetic modifiers of human disease genes, in hopes of shedding light on disease pathophysiology and establishing new therapeutic targets.  The lab staff closely collaborate with experts in carbohydrate biochemistry.  The lab has reported a mouse model for a developmental disorder called Alagille syndrome (ALGS; OMIM 118450), and identified a glycosyltransferase called Poglut1 as a dominant genetic suppressor of the biliary phenotypes in this ALGS model (Thakurdas et al, Hepatology, 2016).  Have also identified a transcription factor as a dominant modifier of the disease phenotypes, whose expression also shows a strong correlation with liver disease severity in human patients (unpublished data).

　　·         Building on these observations, the postdoctoral associate will examine the genetic and transcriptional network involved in ALGS liver abnormalities and will examine the potential utility of these observations for developing therapies for this disease. These studies are likely to provide fundamental insights into normal biliary development and biliary repair in disease contexts.

　　Required: PhD in biomedical science or equivalent

　　·         Experience in mouse genetics and mammalian cell culture is essential.

　　·         Expertise in molecular biology and biochemistry is highly desired.

　　·         The ideal candidate will be a highly motivated and have a strong publication record.

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