招聘簡(jiǎn)介：

　　化學(xué)生物學(xué)和有機(jī)/藥物化學(xué)博士后獎(jiǎng)學(xué)金

　　·圣母大學(xué)

　　·地點(diǎn)：巴黎圣母院

　　·工作編號(hào)：7057647

　　·發(fā)布日期：2019年6月10日

　　·申請(qǐng)截止日期：開(kāi)放至填寫(xiě)

　　工作描述

　　圣母大學(xué)化學(xué)與生物化學(xué)系胡安·德?tīng)?middot;瓦爾教授的實(shí)驗(yàn)室目前正在接受兩個(gè)開(kāi)放博士后職位的申請(qǐng)。

　　第一個(gè)是化學(xué)生物學(xué)領(lǐng)域，研究項(xiàng)目主要集中在蛋白質(zhì)-蛋白質(zhì)相互作用抑制劑和ER應(yīng)激反應(yīng)途徑的生物學(xué)評(píng)價(jià)和表征。這些目標(biāo)的調(diào)節(jié)劑將應(yīng)用于癌癥和神經(jīng)退行性疾病的治療。職責(zé)包括重組蛋白表達(dá)/純化、體外生化分析的開(kāi)發(fā)以及細(xì)胞分析中優(yōu)化抑制劑的評(píng)估。

　　英文原文：

　　Postdoctoral Fellowships in Chemical Biology and Organic/Medicinal Chemistry

　　·         University of Notre Dame

　　·         Location: Notre Dame, IN

　　·         Job Number: 7057647

　　·         Posting Date: Jun 10, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The laboratory of Prof. Juan Del Valle in the Department of Chemistry & Biochemistry at the University of Notre Dame is currently accepting applications for two open Postdoctoral positions.

　　The first is in the area of Chemical Biology, with research projects focused on the biological evaluation and characterization of inhibitors of protein-protein interactions and ER stress response pathways. Modulators of these targets will be applied to the treatment of cancer and neurodegenerative disorders. Duties will include recombinant protein expression/purification, development of in vitro biochemical assays, and evaluation of optimized inhibitors in cellular assays.

　　The second open position is in the area of Organic/Medicinal Chemistry. Duties will include the design and multi-step synthesis of biologically active peptidomimetics and small molecules, and structure-based optimization to target protein-protein interactions.

　　Candidates must have a Ph.D. in Chemistry, Biology, or a related field, and possess excellent written and oral communication skills. Priority will be given to highly motivated, recent Ph.D. graduates with additional experience in one or more of the following areas: drug design, complex molecule synthesis, molecular pharmacology, and structural biology. Involvement in other ongoing interdisciplinary efforts in our laboratory will be an option for interested candidates.

　　Applicants should submit a cover letter indicating the position of interest, complete CV, brief doctoral research summary, and contact information for three references to jdelvalle@nd.edu. Review of applications will begin immediately and continue until the positions are filled. Please visit delvallelab.weebly.com for more information.

　　The University of Notre Dame has exceptional facilities for conducting biomedical research, including state-of-the-art NMR, mass spectrometry, crystallography, microscopy, genomics, and imaging facilities, among others. The successful candidate will have access to an array of resources throughout the College of Science and in the Warren Family Research Center for Drug Discovery and Development, which includes Biological Screening, Chemical Synthesis, and Computer-aided Molecular Design Core Facilities. The Del Valle laboratory and the Warren Center are housed in recently completed McCourtney Hall, a 220,000 square foot building dedicated to research in the molecular sciences and engineering.

　　Postdoctoral Scholars at the University of Notre Dame enjoy a highly competitive compensation and benefits package that includes a retirement plan, medical/dental/vision insurance, paid-time-off, parental leave, and educational reimbursement, among other benefits. The University of Notre Dame seeks to attract, develop, and retain the highest quality faculty, staff and administration. The University is an Equal Opportunity Employee and is committed to building a culturally diverse workplace.

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