招聘簡介：

　　生物醫(yī)學科學：密歇根大學癌癥生物學博士后研究員，安娜堡

　　·密歇根大學

　　·地點：密歇根州安娜堡

　　·工作編號：7057183

　　·發(fā)布日期：2019年5月2日

　　·申請截止日期：2019年7月2日

　　工作描述

　　說明：

　　在密歇根大學安娜堡分校Jolanta Grembecka教授實驗室獲得生物醫(yī)學科學博士后職位，以開展跨學科項目，研究小分子在體外和體內(nèi)癌癥模型中的作用，并采用遺傳方法進行目標驗證研究。我們正在尋找一位積極進取的博士后，在癌癥細胞生物學方面擁有豐富的經(jīng)驗。本研究的重點是評價新型小分子阻斷腫瘤表觀遺傳蛋白的活性和作用機制。這個職位需要在細胞生物學和分子生物學技術(shù)方面的專業(yè)知識，包括PCR，qrt-pcr，western blotting，co-immunosegration，chip，chipseq，流式細胞術(shù)，熒光顯微鏡，免疫染色。有轉(zhuǎn)基因小鼠和異種移植癌模型等動物的工作經(jīng)驗者優(yōu)先。成功的候選人將是一個跨學科團隊的一部分，該團隊專注于新型抗癌藥物候選人的開發(fā)和臨床前評估。

　　英文原文：

　　Biomedical Science: Postdoctoral Fellow in Cancer Biology, University of Michigan, Ann Arbor

　　·         University of Michigan

　　·         Location: Ann Arbor, MI

　　·         Job Number: 7057183

　　·         Posting Date: May 2, 2019

　　·         Application Deadline: Jul 2, 2019

　　Job Description

　　Description:

　　Postdoctoral position in biomedical science is available in Prof. Jolanta Grembecka laboratory, University of Michigan, Ann Arbor, to carry out an interdisciplinary project to study the effect of small molecules in in vitro and in vivo models of cancers and to pursue target validation studies using genetic approaches. We are seeking for a highly motivated postdoctoral fellow with extensive experience in cancer cell biology. The research will be focused on evaluation of the activity and the mechanism of action of novel small molecules blocking epigenetic proteins in cancer. This position requires the expertise in cell biology and molecular biology techniques, including PCR, qRT-PCR, Western Blotting, co-Immunoprecipitation, ChIP, ChIPSeq, flow cytometry, fluorescence microscopy, immunostaining. Prior work experience with animals such as transgenic mice and xenograft models of cancer would be desired. Successful candidate will be a part of an interdisciplinary team focused on development and pre-clinical evaluation of novel anti-cancer drug candidates.

　　Requirements:

　　Applicant must have PhD in biology or related field. The candidates must be a first author on at least 2-3 publications. This position requires extensive experience in cell and molecular biology techniques. Furthermore, excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations.

　　How to apply:

　　Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: jolantag@umich.edu.

　　Contact:

　　Jolanta Grembecka, PhD, Associate Professor

　　Department of Pathology, University of Michigan

　　Ann Arbor, MI, 48109, USA

　　https://www.pathology.med.umich.edu/index.php?t=page&id=1473

　　e-mail: jolantag@umich.edu

　　Relevant publications:

　　1. Borkin, D. et al., Grembecka, J., Pharmacologic inhibition of the menin-MLL interaction blocks progression of

　　MLL leukemia in vivo, Cancer Cell, 2015, 27 (4), 589-602.

　　2. He S, et; al., Grembecka J., Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a

　　fusion partner independent manner. Leukemia. 2016 Feb;30(2):508-13.

　　3. Kempinska K, et al, Grembecka J: Pharmacologic inhibition of the menin-MLL interaction leads to

　　transcriptional repression of PEG10 and blocks hepatocellular carcinoma. Mol Cancer Ther: 2018 Jan;17(1):26-

　　38.

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