招聘簡介：

　　博士后研究員-脂肪組織重塑和代謝紊亂

　　·希望之城

　　·地點：加利福尼亞州杜阿爾特

　　·工作編號：7058164

　　·發(fā)布日期：2019年6月24日

　　·申請截止日期：開放至填寫

　　工作描述

　　希望之城貝克曼研究所正在分子和細胞內(nèi)分泌學系的王瓊博士（安娜貝爾）的實驗室里尋找一位有才華的博士后。

　　王實驗室利用先進的組織特異性、誘導性敲除和譜系追蹤小鼠模型，研究脂肪組織在胰島素抵抗、肥胖和癌癥等生理和病理條件下的區(qū)域特異性重塑。王博士之前已經(jīng)建立了脂肪追逐者小鼠模型，并在脂肪組織發(fā)育和重塑過程中跟蹤脂肪生成（王QA等�！蹲匀会t(yī)學》，2013年）。王博士的另一項研究揭示了體內(nèi)脂肪生成不同階段所需的轉(zhuǎn)錄信號的驚人多樣性（王QA等人《自然細胞生物學》，2015年）。王實驗室目前正在研究兩個項目：1）棕色脂肪組織異質(zhì)性，以及這種異質(zhì)性如何重塑棕色脂肪細胞在健康和疾病中的產(chǎn)熱能力。2）生育期間乳腺中的白色脂肪組織重塑，以及這種重塑如何導致全身代謝紊亂和乳腺癌（王卡，等。細胞代謝，2018年）。

　　我們正在尋找一位積極性很高的博士后研究員，他有興趣研究導致肥胖、糖尿病和癌癥的細胞和代謝機制。這個職位需要在分子生物學和嚙齒動物模型方面有豐富的經(jīng)驗。

　　英文原文：

　　Postdoctoral Fellow - Adipose Tissue Remodeling and Metabolic Disorders

　　·         City of Hope

　　·         Location: Duarte, CA

　　·         Job Number: 7058164

　　·         Posting Date: Jun 24, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the laboratory of Dr. Qiong (Annabel) Wang, in the Department of Molecular and Cellular Endocrinology.

　　The Wang laboratory utilizes the cutting-edge tissue specific, inducible knockout and lineage tracing mouse models to study the region-specific remodeling of adipose tissue, both in physiological and pathological conditions, such as insulin resistance, obesity and cancer. Dr. Wang has previously generated the AdipoChaser mice model and tracked adipogenesis during adipose tissue development and remodeling (Wang QA, et al. Nature Medicine, 2013). Dr. Wang’s another research revealed the surprising diversity of transcriptional signals required at different stages of adipogenesis in vivo (Wang QA, et al. Nature Cell Biology, 2015). The Wang lab is currently working on two projects: 1) Brown adipose tissue heterogeneity, and how this heterogeneity remodels the thermogenic capacity of brown adipocytes in health and disease. 2) White adipose tissue remodeling in the mammary gland during reproduction, and how this remodeling contributes to whole body metabolic disorders and breast cancer (Wang QA, et al. Cell Metabolism, 2018).

　　We are seeking a highly motivated postdoctoral fellow interested in studying the cellular and metabolic mechanisms leading to obesity, diabetes and cancer. The position requires extensive experience in molecular biology and rodent models.

　　Basic education, experience and skills required for consideration:

　　A Ph.D. degree in Molecular, Cellular, or Chemical Biology, or in life or biomedical sciences, or a related discipline is required.

　　Extensive experience with basic molecular biology skills.

　　Extensive experience in animal models.

　　Experience with immunofluorescence staining and flow cytometry.

　　Excellent written and verbal communication skills.

　　Good problem solving skills, ability to conduct independent research, ability to work effectively in a team.

　　Additional Information:

　　To apply, please include your CV and a list of three references.

　　For more information about Dr. Wang’s research, please click here.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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