招聘簡介：

　　博士后研究員-表觀遺傳機制：晝夜節(jié)律時鐘代謝功能

　　·希望之城

　　·地點：加利福尼亞州杜阿爾特

　　·工作編號：7058162

　　·發(fā)布日期：2019年6月24日

　　·申請截止日期：開放至填寫

　　工作描述

　　在霍普市貝克曼研究所糖尿病與代謝研究所的副教授柯馬博士的實驗室里，可以找到一個博士后研究員職位。MA實驗室將最先進的晝夜節(jié)律生物學(xué)、分子生物學(xué)和細胞生物學(xué)方法應(yīng)用于糖尿病和肥胖研究，我們已經(jīng)建立了一個獨特的程序來解釋晝夜節(jié)律時鐘控制代謝組織發(fā)育、生長和功能能力的信號機制。

　　我們正在尋找一位對代謝疾病或干細胞研究有強烈熱情的積極性的博士后研究員，以發(fā)現(xiàn)調(diào)節(jié)脂肪庫和骨骼肌晝夜節(jié)律鐘功能的新表觀遺傳機制。最后，我們的目標是為有針對性的治療干預(yù)揭示當前代謝性疾病流行的生理原因。利用生物化學(xué)和分子生物學(xué)的方法，結(jié)合動物生理學(xué)在遺傳小鼠模型中的應(yīng)用，MA實驗室將探索具體的研究方向：1）外遺傳網(wǎng)絡(luò)介導(dǎo)脂肪組織和骨骼肌中的生物鐘營養(yǎng)傳感功能；2）骨骼肌發(fā)育中干細胞行為的晝夜鐘調(diào)節(jié)。營養(yǎng)、生長和再生；以及3）晝夜節(jié)律調(diào)節(jié)器在癌癥發(fā)展和代謝中的新作用。

　　英文原文：

　　Postdoctoral Fellow - Epigenetic Mechanisms: Circadian Clock Metabolic Function

　　·         City of Hope

　　·         Location: Duarte, CA

　　·         Job Number: 7058162

　　·         Posting Date: Jun 24, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　A Postdoctoral Fellow position is available in the laboratory of Dr. Ke Ma, Associate Professor, at the Diabetes and Metabolism Research Institute within Beckman Research Institute of City of Hope. The Ma lab applies state-of-the-art circadian biology, molecular and cellular biology approaches to diabetes and obesity research, and we have established a unique program in deciphering the signaling mechanisms underlying circadian clock control in metabolic tissue development, growth and functional capacity.

　　We are looking for a highly motivated postdoctoral fellow with strong enthusiasm for metabolic disease or stem cell research to discover novel epigenetic mechanisms mediating circadian clock functions in adipose depots and skeletal muscle. Ultimately, our goal is to unravel circadian etiologies underlying the current epidemics of metabolic diseases for targeted therapeutic interventions. Utilizing biochemical and molecular biology approaches combined with animal physiology in genetic mouse models, the specific research directions in Ma Lab will explore, 1) epigenetic networks mediating clock nutrient-sensing function in adipose tissue and skeletal muscle; 2) circadian clock regulation of stem cell behavior in skeletal muscle development, growth, and regeneration; and 3) novel roles of circadian regulators in cancer development and metabolism.

　　The candidate should be self-motivated, with a proven track record of productivity and strong interest in metabolic disease, epigenetics or stem cell research.

　　For a list of lab publications, please click here.

　　Basic education, experience and skills required for consideration:

　　PhD in Molecular, Cellular or Developmental Biology;

　　Proficiency with biochemical techniques, molecular biology skills and cell culture systems;

　　Highly motivated with strong interest in metabolic disease research;

　　Strong work ethic and ability to work effectively in a team.

　　Preferred education experience and skills:

　　Experience with in vivo animal model research;

　　Experience in biochemistry and gene regulation;

　　Experience with epigenetics research and genomic bioinformatics analysis;

　　Technical skills in metabolic, epigenetics, and stem cell research.

　　Additional Information:

　　For more information about Dr. Ma’s lab, please click here;

　　To apply, please provide your CV, a brief research statement and a list of three references.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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