美國波士頓大學肺部中心博士后職位

　　The Boston University Pulmonary Center, Bosmann Lab is recruiting Postdoctoral Fellows for projects on infection-associated immunology and lung inflammation.

　　Acute respiratory distress syndrome (ARDS) and sepsis are life-threatening complications of bacterial pneumonia with profound disturbances of the immune system. In the current absence of definitive treatment options, ARDS and sepsis represent an enormous problem for health systems worldwide. Our laboratory is dedicated to obtain a better mechanistic understanding of the molecular processes during the pathogenesis of these inflammatory diseases. Several novel transgenic mouse strains generated by our laboratory will be available.

　　We are looking for highly motivated Postdoctoral Fellows to promote our experimental and translational research. Special areas of interest are the role of novel genes involved in inflammation, pathogen recognition, host-pathogen interactions, macrophages, neutrophils, cytokines, and related signaling pathways. The projects will be tailored to meet the individual qualifications and interests of the Fellow. For example, the nature and extent of molecular biology techniques, immunology methods, bioinformatics or a focus on surgical mouse models can be discussed with the applicant.

　　The projects will involve a broad spectrum of immunology methods together with massive parallel sequencing (bulk RNA-Seq, single-cell RNA-Seq) including data analysis. Boston University houses a new Single Cell Core Facility. Another area of interest is genome editing by RNA-guided nucleases (e.g. CRISPR-Cas9) in the mouse germline or cell cultures.

　　The Postdoctoral Fellow will have opportunities in designing as well as conducting independent projects. New graduates and experienced researchers with a strong record of publications are welcome to apply. An MD, PhD or equivalent degree in a relevant field is required and a strong background in Immunology and/or Molecular Biology is preferred. The ability in initiating, conducting, evaluating and reporting of research studies is essential. Funds available include slots for US citizens / Resident Aliens on a T32 grant and affiliation to the Immunology Training Program.

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