美國(guó)密歇根大學(xué)安娜堡校區(qū)化學(xué)方向博士后職位招聘

　　Postdoctoral Research Fellow - Chemistry focused

　　·         University of Michigan

　　·         Location: Ann Arbor, MI

　　·         Job Number: 7063818

　　·         Posting Date: Feb 19, 2020

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The University of Michigan, College of Pharmacy has a full-time opening for a research fellow in the Sun Lab (https://pharmacy.umich.edu/sun-lab).

　　Among other projects, our lab is interested in drug discovery and drug structure optimization for tissue targeting. The goal of our projects is to enhance success rate of drug development in clinical trials by developing methods to optimize compounds for improving efficacy and tissue targeting in relevant disease (Various cancers, Myelofibrosis, Rheumatoid Arthrisis, Ulcerative Colitis). A postdoctoral researcher position in medicinal chemistry is available for a highly motivated individual interested in Activity-DMPK driven structure optimization of small molecules. This position is within a multi-disciplinary and highly collaborative research group. The successful applicant should have a strong background in organic/medicinal chemistry but also show interest in other areas of research relevant to the lab (or to the project) such as, biology and pharmacokinetics.

　　Responsibilities:

　　• Create hypotheses, design compounds, and carry out multi-step synthesis of small molecules

　　• Analyze complex data sets to generate hypotheses for structure and properties optimization

　　• Regular report of research progress in group meeting and active participation in discussion

　　• Work well independently and as a member of a highly collaborative team

　　Required Qualifications:

　　• PhD (or equivalent degree) in Organic/ Medicinal Chemistry

　　• Strong ability to implement synthetic/medicinal chemistry design strategies to address compound liabilities

　　• Solid mechanistic understanding to perform troubleshooting

　　• Experience in molecular modeling or ligand/protein structure visualization to propose hypotheses for optimization (desired but not required)

　　• Good knowledge of common purification and analytical methods such as HPLC, Column chromatography, LC-MS and other related methods

　　• Well organized and ability to multi-task to deliver on multiple targets simultaneously

　　• Excellent communication skills

　　Contact Information:

　　Mady Traore

　　mtraore@umich.edu

　　Pharmaceutical Sciences

　　United States

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