Postdoc Fellow

Harvard Joslin Diabetes Center

Boston, MA, United States

Expires on January 15, 2021

Postdoctoral position at Joslin Diabetes Center / Harvard Medical School

Several postdoctoral positions are available in the context of a long-standing collaborative project between the laboratories of Drs. Peng Yi and Stephan Kissler at the Joslin Diabetes Center / Harvard Medical School.  Their labs use whole-genome CRISPR screening to investigate the mechanism controlling pancreatic beta cell proliferation, regeneration, neogenesis and beta cell protection against autoimmune destruction or alloimmunity in Type 1 Diabetes. The Yi and Kissler labs are affiliated with the Harvard Stem Cell Institute and are part of the recently founded JDRF New England Center of Excellence. The environment at Joslin is highly collaborative and the Yi and Kissler labs have strong ties to several other world-class groups with a focus on beta cell biology, autoimmunity and type 1 diabetes.

Drs. Yi and Kissler also head the core laboratories for CRISPR screening and mouse genome editing at Joslin. The labs have performed a series of whole genome loss-of-function and gain-of-function screens on beta cell protection against autoimmunity. These screens led to the discovery of many novel target genes, signaling pathways and mechanisms that underlie type 1 diabetes onset and beta cell tolerance of autoimmunity.

The successful candidate(s) will be talented and enthusiastic researchers eager to drive projects that aim to understand the mechanism of action of these novel target genes. The research may also entail designing and carrying out new CRISPR screens to investigate pancreatic beta cell compensatory growth, beta cell functions and beta cell tolerance of alloimmunity.

Requirements

·       Ph.D. in genetics, molecular/cellular biology, immunology or related field

·       Basic laboratory methods of molecular cell biology and animal study

·       Established publication record

·       Good communication skills

·       Strong problem-solving skills and ability to work independently and collaboratively

Preferred Skills

Candidates with expertise in ONE or MORE of the following areas will be given priority.

·       Expertise in diabetes related research

·       Expertise in CRISPR technology and gene editing

·       Expertise in genetic screening

·       Expertise in structure-based chemical modeling and designing

·       Expertise in assay development

·       Expertise in biomarker discovery and validation

If you are interested to learn more about our laboratories, please visit our lab websites:

https://www.yi-laboratory.org

https://scholar.harvard.edu/kissler

Applicants should submit a cover letter stating the motivation, a CV and contact information of 3 references to peng.yi@joslin.harvard.edu and Stephan.Kissler@joslin.harvard.edu.  Shortlisted candidates will be contacted for interviews.

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