法國國家科研中心（CNRS）2022年招聘博士后（生物有機與藥物化學）

法國國家科學研究中心（法文：Centre national de la recherche scientifique），簡稱“CNRS”，成立于1939年10月19日，隸屬于法國高等教育和研究部，是法國最大的政府研究機構(gòu)，也是歐洲最大的基礎(chǔ)科學研究機構(gòu)，同時也是世界頂尖的科學研究機構(gòu)之一。它的使命是探索生命世界、物質(zhì)、宇宙和人類社會的運作。CNRS因其在科學領(lǐng)域的卓越貢獻而在國際上享有盛譽，被認為是世界科學技術(shù)發(fā)展的“風向標”。在2020自然指數(shù)排名中，CNRS名列世界第4。

Postdoctoral Fellow M/F In Biorganic And Medicinal Chemistry

Universities And Institutes Of France

Description

Organisation/Company: CNRS

Research Field: Biological sciences Chemistry Pharmacological sciences

Researcher Profile: Recognised Researcher (R2)

Application Deadline: 01/12/2022 23:59 - Europe/Brussels

Location: France › STRASBOURG

Type Of Contract: Temporary

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 01/01/2023

Development of original methodologies in order to remove synthetic barriers and synthesise a library of derivatives of the lead molecules Experimental work Analyses (NMR, HPLC...), structure-activity relationships Writing of scientific reports and publications in English.

This project is part of our research programme dedicated to the optimisation of plasmodione and its superior analogue (bMD40) displaying potent antimalarial redox properties. It includes the development of methodologies allowing the introduction of groups improving the bioavailability of plasmodione, the direct functionalisation of the starting skeleton and the construction of substituted heterocyclic molecules (pyridines, oxetanes, aza- spiroalkanes...) by Suzuki-type pallado-catalysed coupling reactions. The postdoc will be in charge of experimental work, characterizations and analyses (NMR, HPLC...), writing scientific reports and will benefit from an international research environment.

The postdoctoral researcher will work in the "Bio(IN)organic and Medicinal Chemistry" team (UMR 7042 CNRS), headed by Dr Elisabeth Davioud-Charvet. This team develops projects in redox medicinal chemistry to combat several pathogenic parasites in humans. The team includes a physicochemistry research platform supported by an Engineer. In addition to 2 CNRS research directors and 1 CNRS Engineer, the group includes about 2 PhD students and 2 post- doctoral researchers. The laboratory is located at the European School of Chemistry, Polymers and Materials (ECPM) in Strasbourg (CNRS, Universities of Strasbourg and Haute-Alsace) in France. The researcher will work with the students and post-docs under the supervision of the project leader (Dr Elisabeth Davioud-Charvet, DR CNRS). His/her research work will be dedicated to the development of new lead transformations and to the elaboration of new strategies for the synthesis of heterocyclic molecules of interest in order to significantly improve their pharmacokinetic properties. The strengths of the "Bio(IN)organic and Medicinal Chemistry" team lie in the complementarity of skills at the interface of chemistry/enzymology/physicochemistry within the team, the diversity of the teams and expertise that make up the research unit Laboratoired'InnovationMoléculaire et Applications (LIMA), the international recognition of the team and of LIMA, the numerous academic and industrial collaborations, and the technological development, innovation and transfer actions. The team is also attractive for future young researchers wishing to apply for a tenure researcher position at the CNRS thanks to the multiple training opportunities it offers based on its expertise and know-how in terms of design, analysis and discovery of future drugs.

Eligibility criteria

The candidate must have a PhD in organic chemistry. He/she should have a strong background in organic synthesis and synthetic methodologies, and knowledge of medicinal chemistry. Experience in medicinal chemistry (oxetanes, heterocycles) will be an asset. We are looking for an experienced and highly motivated researcher who is committed to the project. In addition, the candidate should have good communication skills and a good team spirit

Additional comments

The application should include the following elements: - A detailed CV including at least two references, who may be contacted. - Master 2 grades, and a cover letter. - A summary of a maximum of 5 pages of past research experience.

Web site for additional job details

https: // emploi.cnrs.fr/Offres/CDD/UMR7042-ELIDAV-003/Default.aspx

Required Research Experiences

RESEARCH FIELD

Chemistry

YEARS OF RESEARCH EXPERIENCE

1 - 4

RESEARCH FIELD

Biological sciences

YEARS OF RESEARCH EXPERIENCE

1 - 4

RESEARCH FIELD

Pharmacological sciences

YEARS OF RESEARCH EXPERIENCE

1 - 4

Offer Requirements

REQUIRED EDUCATION LEVEL

Chemistry: PhD or equivalent

Biological sciences: PhD or equivalent

Pharmacological sciences: PhD or equivalent

REQUIRED LANGUAGES

FRENCH: Basic

Contact Information

Organisation/Company: CNRS

Department: Laboratoired'InnovationMoléculaire et Applications

Organisation Type: Public Research Institution

Website: https:// lima.unistra.fr

Country: France

City: STRASBOURG

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