美國(guó)耶魯大學(xué)兒童研究中心和神經(jīng)發(fā)育與再生項(xiàng)目2024年招聘博士后

耶魯大學(xué)（Yale University），簡(jiǎn)稱“耶魯”或“Yale”，坐落于美國(guó)康涅狄格州紐黑文，是世界著名的私立研究型大學(xué)、全美第三古老的高等學(xué)府、美國(guó)大學(xué)協(xié)會(huì)的14所創(chuàng)始院校之一，也是著名的常春藤聯(lián)盟成員，全球大學(xué)校長(zhǎng)論壇成員。

Postdoctoral Researcher - Yale Child Study Center & Program in Neurodevelopment and Regeneration

Employer

Yale University - Child Study Center

Location

New Haven, Connecticut (US)

Salary

TBD

Closing date

Feb 1, 2024

Discipline

Life Sciences, Biomedical Sciences

Position Type

Full Time

Job Type

Postdoc

Organization Type

Academia

Postdoctoral Associate

Somatic mosaicism and epigenomic regulation in human development and disorders

Flora Vaccarino, PI

A Postdoctoral Associate position is available in the Vaccarino laboratory (https://medicine.yale.edu/lab/vaccarino/) at the Child Study Center, Yale School of Medicine. The lab is in the Sterling Hall of Medicine, in the main Yale Medical School campus.

The lab uses induced pluripotent stem cells (iPSC) and organoid technologies to investigate genomic and epigenomic underpinnings of human brain development. Over the last 10 years, the Vaccarino lab has created a unique resource, a large numbers of human iPSC lines from over 110 individuals comprising clinically characterized cohorts of patients, their first- degree family members, and independent controls. The research focuses on using this unique tool to develop and refine methods for discovery and analysis of noncoding regulatory elements and somatic mutations during human development using advanced molecular, cellular and genomic techniques.

The applicant will be supported by the laboratory’s experience in stem cell technologies and bioinformatic analyses, a library of viral vectors to perform cell type-specific tracing, and microscopic set-up to perform live cell imaging and functional activity studies. The candidate will have the opportunity to collaborate with bioinformaticians involved in the analysis of DNA structural and sequence variants. The applicant will probe the cell types harboring somatic mutations by single cell transcriptome analyses and their functional relevance using CRISPR technologies to engineer mutations in iPSCs lines. Finally, the candidate will take advantage of the superb core facilities at Yale University and will interact with experts in several other disciplines, including geneticists, physiologists, and system biologists.

The candidate must have a Ph.D. and/or M.D., should be an accomplished biomedical scientist with knowledge in molecular and cellular biology, bioinformatics and preferably developmental neuroscience.

Excellent command of the English language is required

Qualified candidates should send a CV, a statement of research interests and the names of two references to:

flora.vaccarino@yale.edu, Lab PI and/or

monica.mleczek@yale.edu, Administrative Assistant

Vaccarino Lab: https://medicine.yale.edu/lab/vaccarino/

Program in Neurodevelopment and Regeneration: https://medicine.yale.edu/neurodevelopment/

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