一、中心簡介

首都醫(yī)學(xué)科學(xué)創(chuàng)新中心（簡稱創(chuàng)新中心）是北京市新成立的具有獨(dú)立法人資格的新型研發(fā)機(jī)構(gòu)。創(chuàng)新中心以推動醫(yī)學(xué)科學(xué)發(fā)展、改善人類健康為目標(biāo)，開展生物醫(yī)學(xué)研究，致力于提升醫(yī)學(xué)科學(xué)創(chuàng)新與成果轉(zhuǎn)化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學(xué)家，與首都醫(yī)學(xué)教育和科學(xué)研究優(yōu)質(zhì)資源緊密合作，打造多學(xué)科交叉融合的科研平臺，綜合自由探索、醫(yī)學(xué)目標(biāo)導(dǎo)向、有組織科研等途徑，實(shí)踐新型科研模式和體制機(jī)制，逐步推進(jìn)醫(yī)教研產(chǎn)的深度融合，培養(yǎng)適應(yīng)醫(yī)學(xué)科學(xué)創(chuàng)新發(fā)展的優(yōu)秀人才。

二、實(shí)驗(yàn)室介紹

首都醫(yī)學(xué)科學(xué)創(chuàng)新中心免疫研究所孫少聰實(shí)驗(yàn)室招聘博士后或副研究員以開展癌癥免疫和自身免疫的基礎(chǔ)和轉(zhuǎn)化研究。本實(shí)驗(yàn)室長期致力于T細(xì)胞的功能和機(jī)制研究。使用信號轉(zhuǎn)導(dǎo)，CRISPR基因篩選，單細(xì)胞RNA測序，和基因敲除小鼠等多種方法研究T細(xì)胞激活，分化，效應(yīng)功能和耗竭的分子機(jī)理，從而鑒定關(guān)鍵性T細(xì)胞調(diào)節(jié)因子。近期工作還包括運(yùn)用生物信息學(xué)手段分析癌癥患者腫瘤測序數(shù)據(jù)庫，鑒定癌癥免疫調(diào)節(jié)因子，然后用小鼠模型進(jìn)行機(jī)理研究。自身免疫研究包括多發(fā)行硬化癥，SLE，和腸炎的小鼠模型。孫教授團(tuán)隊(duì)在該領(lǐng)域已經(jīng)做出了許多影響深遠(yuǎn)的貢獻(xiàn)，包括發(fā)現(xiàn)多種調(diào)節(jié)T細(xì)胞功能和腫瘤免疫/自身免疫的關(guān)鍵因子。這些工作具有很好的轉(zhuǎn)化前景，對藥物開發(fā)和疾病治療有重要指導(dǎo)作用。實(shí)驗(yàn)室也運(yùn)用癌癥免疫治療小鼠模型進(jìn)行轉(zhuǎn)化研究，探索免疫治療的改進(jìn)方法。

三、代表性論文

Nature Cell Biology 24: 1165-1176, 2022, PMID: 35773432

Nature Immunology 22: 193-204, 2021, PMID: 33398181

Nature Cell Biology 21: 1604-1614, 2019, PMID: 31792381

Nature Immunology 20: 879-889, 2019, PMID: 31182807

Nature Immunology 19: 1224-1235, 2018, PMID: 30250187

Nature 545: 365-369, 2017, PMID: 28489822

Nature Immunology 17: 259-268, 2016, PMID: 26808229

Nature Immunology 15: 562-570, 2014, PMID: 24777531

Immunity 40: 692-705, 2014, PMID: 24792914

Nature Medicine 19: 595-602, 2013, PMID: 23603814

Nature 494: 371-374, 2013, PMID: 23334419

四、博士后/副研究員

01、崗位職責(zé)

1.獨(dú)立開展和參與實(shí)驗(yàn)室課題研究工作；

2.協(xié)助PI指導(dǎo)研究生工作。

02、任職要求

1.具有免疫學(xué)相關(guān)領(lǐng)域研究背景，即將或已經(jīng)獲得博士學(xué)位；副研究員需要有博士后研究經(jīng)歷；

2.具備獨(dú)立開展科研工作和指導(dǎo)研究生能力，具有科研熱情和嚴(yán)謹(jǐn)?shù)目蒲袘B(tài)度；

3.具備熟練的英文交流和讀寫能力，可以獨(dú)立撰寫英文論文；

4.有扎實(shí)的免疫學(xué)、信息生物學(xué)、小鼠腫瘤免疫或自身免疫模型試驗(yàn)背景者優(yōu)先考慮。

五、福利待遇

1.根據(jù)應(yīng)聘者的工作經(jīng)驗(yàn)和能力，提供具有市場競爭力的薪酬（詳情面談）；

2.享受五險(xiǎn)一金、帶薪年假、體檢和補(bǔ)充醫(yī)療保險(xiǎn)等；

3.支持個人職業(yè)發(fā)展，提供必要的工作相關(guān)專業(yè)培訓(xùn)。

六、申請方法

應(yīng)聘者請將個人簡歷、研究興趣或計(jì)劃，以及2-3名推薦人的姓名及聯(lián)系方式，以及其他能證明科研能力的相關(guān)電子文件發(fā)送到郵箱 ssun@cimrbj.ac.cn，郵件主題請注明“應(yīng)聘者名字+具體應(yīng)聘職位”。

聯(lián)系人：孫老師

聯(lián)系地址：北京市豐臺區(qū)右安門外西頭條10號-首都醫(yī)學(xué)科學(xué)創(chuàng)新中心

本招聘長期有效，至招聘到合適人選為止。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The laboratory of Shao-Cong Sun at the Chinese Institutes for Medical Research (CIMR) is recruiting motivated Postdoctoral Fellows and Research Associate Investigators to conduct basic and translational research in Cancer Immunology and Autoimmunity.A major focus of the lab is to study the molecular mechanisms that regulate T cell activation, differentiation, effector function, and exhaustion using a variety of cutting-edge techniques, such as signal transduction, CRISPR library screening, single-cell RNA sequencing, and knockout mouse models.Our recent work also includes the use of bioinformatics to analyze tumor sequencing databases of cancer patients, identify cancer immunomodulators, and then conduct mechanistic studies using mouse models.Autoimmune studies include mouse models of multiple sclerosis, SLE, and colitis.Professor Sun's team has made many significant contributions in this field, including the discovery of key factors regulating T cell functions in autoimmunity and cancer immunity.Our work also has strong translational potential and plays an important guiding role in drug development and disease treatment.The laboratory also uses mouse models of cancer immunotherapy to conduct translational studies and explore improved methods of immunotherapy.

Representative Publications

Nature Cell Biology 24: 1165-1176, 2022, PMID: 35773432

Nature Immunology 22: 193-204, 2021, PMID: 33398181

Nature Cell Biology 21: 1604-1614, 2019, PMID: 31792381

Nature Immunology 20: 879-889, 2019, PMID: 31182807

Nature Immunology 19: 1224-1235, 2018, PMID: 30250187

Nature 545: 365-369, 2017, PMID: 28489822

Nature Immunology 17: 259-268, 2016, PMID: 26808229

Nature Immunology 15: 562-570, 2014, PMID: 24777531

Immunity 40: 692-705, 2014, PMID: 24792914

Nature Medicine 19: 595-602, 2013, PMID: 23603814

Nature 494: 371-374, 2013, PMID: 23334419

Open Positions

Postdoctoral Fellows /

Research Associate Investigators

Main Responsibilities

a.Carrying out research projects independently.

b.Assisting PI to mentor graduate student.

Qualifications

a.With research background in immunology related biomedical fields, either about to obtain or having already obtained a doctoral degree; postdoctoral experience is required for research associate investigator position.

b.With motivation and ability to independently carry out research projects and supervise graduate students, and have strong motivation in scientific research.

c.Proficient in English reading, writing, and daily communication; capable of writing papers in English.

d.Those with solid background in immunology, bioinformatics, mouse models of cancer immunity or autoimmunity, or CRISPR screen will be given priority.

Welfare Treatment

a.Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b.Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c.Support career development, provide relevant professional guidance.

How to apply

To apply, please send personal resume, research interest or plan, the names and contacts of 2-3 referees and other materials demonstrating research capabilities to ssun@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.

Contact person: Dr.Sun

This recruitment is valid for the long term until a suitable candidate is recruited.

信息來源于網(wǎng)絡(luò)，如有變更請以原發(fā)布者為準(zhǔn)。

來源鏈接：

https://mp.weixin.qq.com/s/826vE_T8fw2KtdqX0VhpQQ

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）