博后招聘——30 萬年薪，“生物-醫(yī)學-信息-工程”學科交叉，國際名校合作研究
Postdoctoral Researcher Recruitment

WHO WE ARE

浙江大學愛丁堡大學聯(lián)合學院（ZJE）坐落于浙江大學海寧國際校區(qū)，是由浙江大學（2019QS世界排名第54位）和英國愛丁堡大學（2019QS世界排名第20位）合作成立的非獨立法人中外合作辦學機構(gòu)，專注于探索“生物-醫(yī)學-信息-工程”學科交叉研究。

The Zhejiang University-University of Edinburgh Institute (ZJE) is based in state of the art facilities at the new International Campus in Haining, Zhejiang, P.R.China. The new Institute, established by two world-leading universities, Zhejiang University and University of Edinburgh, is focused on international Biomedical Sciences/Bioinformatics/Biomedical Informatics/Biomedical Engineer research collaboration.

ZJE正與浙江大學醫(yī)學院附屬第二醫(yī)院開展戰(zhàn)略合作，探索以疾病診療為導向的生物醫(yī)學前沿聯(lián)合研究。

ZJE is carrying out strategic cooperation with the Second Affiliated Hospital of Zhejiang University School of Medicine to explore frontier research on biomedical sciences oriented by disease diagnosis and treatment.

了解更多信息，請查閱以下網(wǎng)址：

To learn more information about the institute, please refer to the websites below:

http://zje.zju.edu.cn (ZJE, 浙江大學愛丁堡大學聯(lián)合學院)

http://www.intl.zju.edu.cn (International Campus, ZJU, 浙江大學海寧國際校區(qū))

http://www.zju.edu.cn (Zhejiang University，浙江大學)

https://www.ed.ac.uk (the University of Edinburgh，愛丁堡大學)

http://www.z2hospital.com (the Second Affiliated School of Zhejiang University School of Medicine，浙江大學醫(yī)學院附屬第二醫(yī)院)

WHAT WE ARE LOOKING FOR

ZJE面向全球誠聘博士后研究人員，學科領(lǐng)域涵蓋干細胞和再生醫(yī)學、免疫學、生物化學和分子生物學、細胞生物學和病原微生物學等。

ZJE is now seeking applications for postdoctoral positions from around the world. Research themes include: Stem Cell and Regenerative Medicine, Immunology, Biochemistry and Molecular Biology, Cellular Biology, Pathogenic Microbiology.

應(yīng)聘要求Qualifications

申請者需擁有生物學、醫(yī)學、生物醫(yī)學、生物信息學和公共健康等相關(guān)領(lǐng)域博士學位，已在國際刊物上發(fā)表過較好研究論文者優(yōu)先考慮。

Applicants will be expected to have a PhD in biology, medical science, biomedical science, bioinformatics, public health or a related field and show evidence of their research achievements and potential.

導師和項目詳情For more information about projects and mentors:

干細胞和再生醫(yī)學Stem Cell and Regenerative Medicine：

歐陽宏偉Hongwei Ouyang: hwoy@zju.edu.cn

個人主頁Website: http://person.zju.edu.cn/en/ouyanghongwei

研究領(lǐng)域Research:

歐陽宏偉教授長期從事干細胞與骨、軟骨、肌腱組織的再生研究，先后獲批國家級、省部級科研項目近20項。

Prof. Ouyang Hongwei focuses on the research of stem cell and regenerative medicine, sports medicine, tissue engineering and biomedical materials.

黃雯雯Wenwen Huang: wenwenhuang@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/wenwenhuang

研究領(lǐng)域Research:

本課題組致力于設(shè)計開發(fā)具有特定功能的人造蛋白材料，以滿足當前資源、能源、環(huán)境等可持續(xù)發(fā)展策略對新材料的迫切需求。本實驗室通過將生物物理、生物工程以及醫(yī)學等領(lǐng)域進行交叉融合，建立了以蛋白功能為導向、以生物合成和多尺度模擬為基礎(chǔ)、以高通量制備分析和功能測試為驗證和優(yōu)化手段的人造蛋白功能材料創(chuàng)制體系。主要研究方向為（1）蛋白質(zhì)序列-結(jié)構(gòu)-功能的關(guān)系以及蛋白質(zhì)材料對人體組織/細胞生長分化的影響；（2）智能蛋白質(zhì)材料設(shè)計、高通量篩選、蛋白質(zhì)自組裝理論研究和蛋白質(zhì)材料物理化學改性；（3）蛋白質(zhì)基柔性電子設(shè)備研發(fā)等應(yīng)用方面的研究工作。

Dr. Huang’s lab focuses on predictive design, synthesis and functionalization of protein-based biomaterials for regenerative medicine and sustainable bio-electronics. Current research projects include: (1) injectable hydrogel and stem cell engineering, (2) stimuli-responsive biomaterial design, and (3) flexible electronics. Postdoc positions are available for highly motivated candidates with expertise in synthetic biology, material science and stem cell engineering.

劉琬璐Wanlu Liu: wanluliu@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/labw

研究領(lǐng)域Research:

本課題組通過多學科交叉，結(jié)合基因組學(RNA-seq, Bisulfite sequencing, ChIP-seq, ATAC-seq, Hi-C, single cell-based sequencing)、分子生物學以及生物信息學，來研究表觀遺傳在調(diào)控細胞 命運決定過程中的起到的在基礎(chǔ)科學層面以及臨床轉(zhuǎn)化方面相關(guān)的問題。主要的研究方向包括:1)研究轉(zhuǎn)座子在細胞命運決定過程中涉及的表觀遺傳調(diào)控相關(guān)問題。2)開發(fā)用于預(yù)測細胞命運的基于機器學習/深度學習相關(guān)的基因組學算法。3) 基于表觀遺傳組學的疾病分型以及疾病預(yù)測。

1) understand the epigenetic basis of transposable elements in cell fate descisions. 2) develop machine learning based algorithm to predict cell fate.

陳迪Di Chen: dichen@intl.zju.edu.cn

個人主頁Website: http://labchen.cn

研究領(lǐng)域Research:

陳迪博士的實驗室研究人類胚胎發(fā)育和胚胎干細胞分化的調(diào)控。目前，陳迪實驗室招聘數(shù)位博后，主要研究課題包括：

（1）人類胚胎干細胞分化在表觀遺傳層面以及轉(zhuǎn)錄后層面的調(diào)控。

（2）RNA-結(jié)合蛋白在人類原始生殖細胞誘導和分化過程中的功能。

（3）決定細胞命運的轉(zhuǎn)錄因子在人類胚胎干細胞分化過程中的新功能。

Dr. Chen’s lab focuses on the regulation of human embryogenesis and embryonic stem cell differentiation. Postdoc positions are available in Chen lab for the following projects

(1) The regulation of human embryonic stem cell differentiation at epigenetic and post-transcriptional levels.

(2) The function of RNA-binding protein during human primordial germ cell specification and differentiation.

(3) The new functions of cell fate determinant transcription factors during embryonic stem cell differentiation.

生物化學和分子生物學Biochemistry and Molecular Biology

Sebastian Leptihn: leptihn@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/H118035

研究領(lǐng)域Research: The Leptihn Group offers two Postdoctoral Fellowships; one project focusses on the investigation of membrane proteins controlling cellular signalling pathways employing microfluidics and single molecule methods (fluorescence, electrophysiology) together with the University of Edinburgh and the ZJUI (Zhejiang University-University of Illinois Urbana Champagne). The second project involves viruses of microbes (bacteriophages) with aspects on both, function and structure of phage proteins, as well as phage therapy. Experience in imaging and protein biochemistry or microbiology are desired.

洪智Zhi Hong: zhihong@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/hongzhi

研究領(lǐng)域Research:

本課題組將從細胞器交流角度解析細胞-外界環(huán)境的相互作用，即外界環(huán)境變化（特指外源的能量供給變化）對細胞器互作結(jié)構(gòu)特質(zhì)（property）/穩(wěn)態(tài)（homeostasis）的影響。直接研究方向主要集中在兩個方面：1）結(jié)合領(lǐng)域內(nèi)已知和本人的前期數(shù)據(jù)，對細胞器互作網(wǎng)絡(luò)改變細胞器膜脂組成和蛋白成分進行深入的機制研究。2）利用新的生物標記或技術(shù)從亞細胞器水平上發(fā)現(xiàn)細胞器互作網(wǎng)絡(luò)對單個細胞器的影響，進一步拓展我們對細胞器互作網(wǎng)絡(luò)的功能認知。

1. The regulation of organelle-organelle crosstalk on biogenesis-maturation- location of organelles.

2. The function or contribution of organelle-organelle crosstalk in stress response.

病原微生物學Pathogenic Microbiology

Sue Welburn: sue.welburn@ed.ac.uk

個人主頁Website:http://www.ed.ac.uk/pathway-medicine/our-staff/staff-profiles/profsuewelburn

研究領(lǐng)域Research:

Sue focuses on interventions for disease control in the Global South, with on-going projects in Kenya, Morocco, Mozambique, Tanzania, Uganda, Nigeria, Zambia and Zanzibar.

免疫學Immunology

魯林榮Linrong Lu：lu_linrong@zju.edu.cn

個人主頁Website: http://person.zju.edu.cn/en/llr

研究領(lǐng)域Research:

本實驗室旨在用分子生物學、細胞生物學和實驗動物模型等研究手段揭示免疫調(diào)節(jié)的機制。尤其對胸腺T細胞發(fā)育、CD8+ T細胞亞群和具有免疫調(diào)節(jié)功能新分子的研究感興趣，同時對自身免疫性疾病和腫瘤的免疫治療的策略進行研究。

研究手段：分子生物學，細胞培養(yǎng)，基因敲除，自身免疫性疾病動物模型

正在開展的課題：

1）CD8+ T細胞亞群與自身免疫性疾病與抗腫瘤免疫

2）胸腺T細胞的發(fā)育分化

3）T細胞分化的信號傳導調(diào)控

4）固有免疫的信號傳導和基因表達調(diào)控

The main focus of our lab is to elucidate the molecular pathways and cellular interactions that mediate and regulate thymocyte development and T cell-mediated immune responses by using molecular biology and genetic approaches. We are especially interested in the identification and characterization of novel immune-related molecules and the development and treatment of autoimmune diseases.

細胞生物學Cellular Biology

郭偉Wei Guo: weiguo@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/gwlab

研究領(lǐng)域Research:

郭博士從事干細胞和癌癥的研究，精于人類和小鼠遺傳學，分子生物學，細胞生物學，生物醫(yī)學，及基因組學的方法。他在造血發(fā)育、白血病干細胞以及腫瘤耐藥調(diào)控方面等有重要建樹。他建立了第一個由PTEN缺失導致T細胞急性白血病的小鼠模型，促成臨床發(fā)現(xiàn)只帶有PTEN突變而沒有NOTCH1突變的嬰幼兒T細胞白血病病人。他首次分離了T細胞急性白血病干細胞，揭示出了多因子突變導致白血病干細胞形成的過程，并發(fā)現(xiàn)了mTOR抑制劑的雙重抗癌機制。近來，郭博士課題組從臨床肺腫瘤中分離出腫瘤干細胞，并發(fā)現(xiàn)NOTCH1信號通路調(diào)控肺腫瘤干細胞的自我更新和鉑類耐藥。

Dr. Wei Guo laboratory uses basic biological approaches to understand biomedical challenges and translates its understanding to clinical practice. There are two major research directions: (1) stress response and ex vivo expansion of hematopoietic stem cells; and (2) regulation and targeted inhibition of cancer resistance.

謝昕Xin Xie: xinxie@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/xinxie

研究領(lǐng)域:

研究方向：課題組運用分子生物學、細胞生物學、生物信息學、3D類器官培養(yǎng)和轉(zhuǎn)基因小鼠模型研究干細胞命運控制，衰老及相關(guān)疾病的靶向治療。

正在開展的課題：

1）腸干細胞穩(wěn)態(tài)平衡、惡性轉(zhuǎn)化及腸道疾病的早期診療。運用生物信息學分析、小鼠模型和腸道類器官，我們將深入研究大腸腫瘤干細胞的惡性轉(zhuǎn)化和腫瘤轉(zhuǎn)移的分子機制，并開展臨床轉(zhuǎn)化研究。

2）干細胞發(fā)育、衰老和融合的信號調(diào)控。實驗室的最新成果揭示了首個永久性的阻斷體內(nèi)細胞融合的動物模型。在此基礎(chǔ)上，我們將進一步探討細胞融合與衰老的分子機理。

3）肌肉萎縮癥，糖尿病和肥胖的靶向治療。實驗室已發(fā)表的研究證實了新的疾病治療靶點。為此，我們將運用高通量篩選實驗找尋靶點基因的小分子抑制劑，進行臨床前期研究。

We investigate signaling molecules within adult stem cells (intestinal、muscle and mesenchymal stem cells) regulate their fundamental properties in both physiological and pathological conditions.

Research interest: adult stem cell and related disorders

1. Intestinal stem cell, colorectal cancer and inflammatory bowel disease

2. Mesenchymal stem cell, muscle stem cell, musculoskeletal disorders and metabolic syndrome

Mikael Bjorklund: mikaelbj@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/H118035

研究領(lǐng)域Research:

本實驗室主攻癌癥細胞生物學，致力于腫瘤細胞生長和代謝(參見我們的論文《Dev Cell, 2016》，《Trends in Cell Biology, 2017》)。我們使用定量和基因組數(shù)據(jù)來了解細胞大小、細胞生長和代謝之間的關(guān)系。我們實驗室在熱蛋白組學分析處于前沿行列（參見我們的論文《EMBO J, 2018》），并以此技術(shù)來研究藥物和代謝物與細胞蛋白之間的相互作用。我們的項目結(jié)合了信息學和實驗細胞生物學，因此我們非常歡迎來自不同科學背景的候選人提出申請。具有生物信息學、計算機科學或物理學背景者將優(yōu)先考慮。

Mikael Bjorklund lab works on cancer cell biology, focusing on cell growth and metabolism (Dev Cell, 2016; EMBO J, 2018). The main interest in the laboratory is how metabolism, particularly mitochondria, and cell size impact cellular fitness and functions.

Ting Gang Chew: tinggchew@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/H118023

研究領(lǐng)域Research:

細胞通過感知和轉(zhuǎn)導機械力信號來產(chǎn)生恰當?shù)陌麅?nèi)生物化學應(yīng)答。細胞內(nèi)外的機械力都有助于胞質(zhì)分裂的成功，從而使一個細胞分裂為兩個子細胞。研究表明細胞胞質(zhì)分裂的失敗與基因組不穩(wěn)定性、腫瘤進化和衰老緊密關(guān)聯(lián)，而胞質(zhì)分裂的成功則與細胞動力學和細胞外基質(zhì)的相互作用密切相關(guān)。我們的研究目的是探究胞質(zhì)分裂在衰老或其它病理狀況下的對細胞外基質(zhì)不同剛度反應(yīng)的機械力學和動力學機制。為此，我的實驗室聯(lián)合采用化學遺傳學、光遺傳學和高分辨率活細胞顯微成像技術(shù)探究胞質(zhì)分裂失敗產(chǎn)生的結(jié)果和胞質(zhì)分裂的機械生物學機制。

Cells sense and transduce mechanical signals to generate appropriate biochemical and cellular response. Both the cellular and extracellular mechanics contribute to the success of cytokinesis, which is the division of one cell into two. Failure of cytokinesis is implicated in genomic instability, tumor evolution, and aging. The success of cytokinesis is linked to the proper interaction of cytokinetic machinery and the extracellular matrix. We aim to study the mechanics and dynamics of cytokinesis in response to different extracellular matrix stiffness during aging or other pathological conditions. To this end, my lab couple chemical genetics, optogenetics and high resolution live cell microscopy imaging to study the mechanobiology of cytokinesis and the consequences of its failure.

王超塵Chaochen Wang： chaochenwang@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/H118068

研究領(lǐng)域Research:

實驗室充分利用高通量測序，以CRISPR介導的基因編輯和表觀遺傳編輯為主要技術(shù)手段，結(jié)合生物信息學分析,  充分結(jié)合基因組學、表觀遺傳學、信息學、基因編輯技術(shù)和動物體內(nèi)篩選模型，致力于以臨床疾病為導向的表觀遺傳學方向的研究。研究方向分為基礎(chǔ)和臨床研究兩個部分，并相互交叉。

實驗室目前主要研究方向包括：

1）細胞命運改變的表觀遺傳調(diào)控機制研究

2）基因編輯及表觀遺傳編輯工具研究

3）乳腺發(fā)育及乳腺癌發(fā)生的分子機制及免疫調(diào)節(jié)機制研究

Dr Chaochen Wang’s lab focuses on dissecting the molecular mechanisms underlying the cell fate transition during ESC differentiation, mammary gland development and tumorigenesis. Leveraging CRISPR-mediated genome and epigenome engineering tools, NGS and bioinformatics, his lab aims for making prominent impact on stem cell study, cancer diagnosis and prognosis in a long run.

Kuan Yoow Chan: kychan@intl.zju.edu.cn

個人主頁Website: https://person.zju.edu.cn/en/H118031

研究領(lǐng)域Research:

The centrosome is an important signalling and microtubule organizing centre in mammalian cells. Centrosomal defects are a common in high grade cancer and have been shown to trigger tumorigenesis in mice. The impact of centrosomal defects in deregulating the cell cycle in cancer is poorly understood. In addition, cancer genome sequencing efforts worldwide show mutations on centrosomal components are common. Using genetic, cell biology and biochemical assays, we aim to study how the changes in centrosomal signalling lead to the deregulation of the cell cycle in cancer.

WHAT WE OFFER

應(yīng)聘者將與浙江大學簽訂合同，工作地點為海寧國際校區(qū)。

The posts will be located at ZJE Institute in Haining and the contract of employment will be held with Zhejiang University.

薪資及待遇Salary and Benefits

1）薪資待遇參照浙江大學博士后招聘相關(guān)政策執(zhí)行，年薪最高可達人民幣30萬元。

Salary is commensurate with qualifications and experience, compliant with policies for postdoctoral recruitment in Zhejiang University. Annual pay is in the region of 300,000 RMB.

2）學校有償提供教師公寓（優(yōu)惠價格租賃）、支持申請國家自然科學基金，鼓勵支持在站期間申報各類博士后基金和國際交流專項計劃資助。

Postdoc Fellows is eligible to rent staff apartments at favorable price, and is encouraged to apply for NSFC、Postdoctoral Funding and International Exchange Funding.

3）ZJE為博士后研究人員提供國際化科研環(huán)境以及國際學術(shù)交流的機會。

ZJE provides an excellent research environment and opportunities for international academic exchange.

HOW TO APPLY

應(yīng)聘材料Application Materials：

1） 簡歷Your CV

2）學歷學位證書Certificates of education experience

3）科研經(jīng)歷和學術(shù)成就簡述A summary of your research experience to date

4）2封推薦信（其中一封來自博士期間導師）Two references from experts in your scientific field (one from your PhD supervisor)

請將應(yīng)聘材料直接發(fā)至你感興趣的導師郵箱，或發(fā)給學院公共郵箱（uoe@zju.edu.cn）并注明感興趣的導師。

Email to mentors whose research fields fit yours or to our admin team (uoe@zju.edu.cn).

為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標題格式：應(yīng)聘職位名稱+姓名+學歷+專業(yè)+中國博士人才網(wǎng)）