德國基爾亥姆霍茲海洋研究中心2024年招聘博士后（微生物天然產(chǎn)物化學(xué)）

Post-doctoral researcher (m/f/d) in (Marine) Microbial Natural Product Chemistry

Employer

Helmholtz Centre for Ocean Research Kiel (GEOMAR)

Location

GEOMAR Helmholtz Centre for Ocean Research Kiel, Wischhofstraße 1-3, 24148 Kiel, Germany

Salary

The salary depends on qualification and could be up to the class 13 TVöD-Bund of the German tariff

Closing date

16 Sep 2024

Project Description:

BlueHealthTech links competencies in Kiel area in marine research (Blue), health care and industry (Health) to generate novel technological approaches to improve the diagnosis, monitoring and treatment of chronic diseases. The program exploits the regionally available technical and analytical knowledge for sustainable development of innovative health technologies (Tech) in new multidisciplinary partnerships.

Osteopenic diseases, such as osteoporosis, osteoarthritis and bone degeneration, pose significant health and economic challenges to the aging society. Bone morphogenetic proteins (BMPs), which are cytokines with central functions in tissue homeostasis and regeneration, hold osteoinductive properties, hence are of great importance for bone regeneration. Marine microorganisms have enormous biosynthetic capability for producing novel and bioactive metabolites with pharmaceutical relevance. The main aim of the MorphoMarin project is the discovery of novel marine microbial metabolites as first-in-class BMP activators. The project brings together microbial biotechnology using computational metabolomics- and bioactivityguided marine natural product chemistry with high throughput stem-cell based phenotypic assay technology to identify safe, selective BMP activators for use in regenerative medicine.

Job Description:

We are seeking a highly skilled post-doctoral researcher with demonstrated expertise in marine microbial biotechnology, i.e., microbial cultivation, extraction, downstream metabolomics and natural product chemistry. The candidate will culture/upscale the most active strains to be followed by i) LC-MS/MS-based untargeted metabolomics analysis ii) fractionation iii) mass spectrometry- and bioactivity-guided purification and iv) structure elucidation of BMBPactivating microbial metabolites. The post-holder will work closely with our project partner at Kiel University in high throughput stem-cell based phenotypic assays. He/she will actively manage the project and related administrative tasks. The candidate will be expected to write publications/patents/project reports and contribute to assessment of project results for potential development.

This is a unique opportunity for an ambitious post-doctoral researcher to further develop their career on marine microbial drug discovery that can make impact on the quality of human life.

Qualifications required:

A diploma and a PhD in microbial natural product chemistry, preferably on marine microbes

Hands-on experience in cultivation/fermentation and extraction of (marine) microorganisms

A strong background and hands-on experience in dereplication/metabolomics of natural products by LC-MS/MS (preferably by molecular networks)

Competence and hands-on experience in purification of natural products (by HPLC and other chromatographic methods)

Demonstrated competence in structure elucidation of natural products by 1D and 2D NMR, HRMS, other spectroscopic and computational methods

Proficiency in use of software and databases (for dereplication) and statistical analysis

Demonstrated experience in writing first author-publications, excellent publication track record in scientific journals and conference presentations

Excellent communication skills in English (both spoken and written)

Advantageous skills:

Previous post-doctoral experience on marine microbial natural product chemistry

A full car driving license

Experience in working as part of an interdisciplinary team

Good communication skills in German.

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